Fish oils and cardioprotection – mechanisms explored

November 2002    Volume 9, Issue 10   Br J Cardiol 2002;9:609-10

Authors:
Derek M Yellon, Derek Hausenloy

Interest in the cardioprotective properties of marine omega-3 polyunsaturated fatty acids (n-3 PUFAs) has been renewed following the publication of three large trials earlier this year demonstrating a reduction in sudden cardiac deaths from the ingestion of marine n-3 PUFAs, along with the recent availability in the UK of its pharmacological equivalent, Omacor™. Secondary prevention trials, such as the Diet and Reinfarction Trial (DART) and the more recent analysis of the GISSI-Prevenzione data, found a reduction in sudden deaths associated with supplementation of n-3 PUFAs in post-myocardial infarction patients.1,2

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