The role of homocysteine in the clinical assessment of cardiovascular risk

March 2003    Volume 10, Issue 2   Br J Cardiol 2003;10:118-22

Authors:
Jennifer Bexley

Clinical and epidemiological studies suggest elevated levels of total plasma homocysteine (> 15 µmol/L) are associated with an increased risk of cardiovascular disease, independent of other known risk factors. This review outlines the causes of hyperhomocysteinaemia, current evidence of a positive association with cardiovascular disease, and how such findings may have important implications for future assessments of risk and nutritional recommendations, particularly for those with a previous or family history of cardiovascular disease.

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