Rhabdomyolysis and acute renal failure due to simvastatin and amiodarone

September 2007    Volume 14, Issue 4   Br J Cardiol 2007;14:242-44

Authors:
Haroon Siddique, Maria Mushkbar, Adrian Walker, John Scarpello

Rhabdomyolysis is an uncommon but potentially serious adverse reaction associated with the use of statins. Simvastatin is metabolised by cytochrome P450 CYP3A4 and amiodarone is an inhibitor of this enzyme. Concomitant use of these drugs, especially with high doses of simvastatinm may result in myopathy. Acute renal failure as a result of rhabdomyolysis due to this aetiology is rare with only a few cases reported previously. Here, we report a case of rhabdomyolysis and acute renal failure secondary to concomitant use of simvastatin and amiodarone.

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