Switching statins: the impact on patient outcomes

November 2007    Volume 14, Issue 5   Br J Cardiol 2007;14:280-5

Authors:
Berkeley Phillips, Fayaz Aziz, Christopher P O'Regan, Craig Roberts, Amy E Rudolph, Steve Morant

Little is currently known of the effect of switching statin therapy on cardiovascular outcomes. Using The Health Improvement Network database, patients who had received atorvastatin for ≥ six months were identified. They were classified as ‘switch’ if they were subsequently switched to simvastatin, and were matched to up to four ‘control’ patients who remained on atorastatin. Time to death or first major cardiovascular event was compared, controlling for the matching co-variates, prior statin exposure and baseline cholesterol concentration.

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