New ‘healing’ stent looks promising

January 2008    Volume 15, Issue 1   Br J Cardiol 2008;15:7-11

Authors:
BJCardio editorial team

A new stent which may promote healing of the artery better than currently available drug-eluting stents has shown promising results in initial clinical trials. The Genous Bio-engineered R StentTM, being developed by OrbusNeich, is coated with an antibody to capture a patient’s endothelial progenitor cells, which form a layer over the stent to provide protection against thrombus and minimise restenosis.

In the current study, the Genous^TM stent was associated with significantly fewer major adverse cardiac events (MACE) than the Taxus^TMor Cypher^TM drug-eluting stents. The study, presented at the recent Italian Society of Invasive Cardiology by Dr Federico Piscione (Federico II University of Naples, Italy) involved 195 high-risk patients who received either a Genous^TM, Taxus^TM or Cypher^TM stent. Dual antiplatelet therapy was given for one month to the patients receiving a Genous^TM stent and for nine months to those given one of the drug-eluting stents.

“Genous^TM is a viable alternative to drug-eluting stents, which have raised many safety concerns among the interventional cardiology community,” Dr Piscione concluded.

A large phase III trial of the Genous^TM stent is now underway.

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