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November 2008 Br J Cardiol 2008;15:316-21

Vascular calcification: mechanisms and management

Smeeta Sinha, Helen Eddington, Philip A Kalra

Abstract

Introduction Figure 1. Plain X-rays of calcified vessels: (A) calcified peripheral vessels; (B) calcified iliac vessels Chronic kidney disease (CKD) is thought to affect approximately one in 10 people and approximately 0.2% of the population has end-stage renal disease (ESRD).1 Patients with CKD have significantly increased cardiovascular morbidity and mortality in comparison with the general population. As CKD progresses towards ESRD the cardiovascular event risk increases.2 This is thought to occur from a combination of increased atherosclerotic disease and increased prevalence of vascular calcification (VC) (figures 1 and 2). Figure 2. Com

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