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Tag Archives: heart failure

Mild hyponatraemia and short-term outcomes in patients with heart failure in the community

June 2011 Br J Cardiol 2011;18:133–7

Mild hyponatraemia and short-term outcomes in patients with heart failure in the community

Sudip Ghosh, Jude Smith, Jonathan Dexter, Colette Carroll-Hawkins, Noel O’Kelly

Abstract

Introduction Hyponatraemia is a common electrolyte disorder among patients with heart failure (HF), nephrotic syndrome or cirrhosis.1-3 It is recognised as a predictor of adverse outcomes in hospitalised patients with these conditions,4-5 and its prognostic implications are commonly attributed to the severity of the underlying pathology. Patients admitted to hospital with decompensated heart failure have a poor prognosis, with in-hospital mortality rates approaching 10%.5-7 Hyponatraemia associated with decompensation results in added adverse outcomes resulting in high 30–90-day mortality and re-hospitalisation rates.5-9 These results have

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News from the American Heart Association Scientific Sessions 2010

February 2011 Br J Cardiol 2011;18:11-3

News from the American Heart Association Scientific Sessions 2010

Abstract

Highlights of the American Heart Association 2010 meeting held in November 2010, in Chicago, USA, included a breakthrough for the treatment of resistant hypertension, and another oral anticoagulant that could be used instead of warfarin in atrial fibrillation patients, without the need for monitoring. RAFT: CRT reduces deaths and hospitalisations in mild heart failure Adding cardiac-resynchronisation therapy (CRT) to implantable cardioverter defibrillator (ICD) and medication, led to a reduction in deaths and heart failure hospitalistions among patients with mild-to-moderate symptoms of heart failure in the RAFT (Resynchronisation-Defibrilla

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Drugs for diabetes: part 3 thiazolidinediones

February 2011 Br J Cardiol 2011;18:24-7

Drugs for diabetes: part 3 thiazolidinediones

David McGrane, Miles Fisher, Gerard A McKay

Abstract

Introduction During the past 10 to 15 years, numerous drugs have been introduced for the treatment of patients with type 2 diabetes to prevent the complications of poor glycaemic control. Two such oral drugs, rosiglitazone and pioglitazone, belong to the class of drugs called thiazolidinediones (TZDs), also known as glitazones. Both were licensed for use as monotherapy or in combination with other hypoglycaemic drugs. Through their actions on peroxisome proliferator-activated receptor (PPARγ), they improve hyperglycaemia and alter dyslipidaemia. It was hoped this would translate into cardiovascular benefits for patients taking them. Recent e

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September 2010 Br J Cardiol 2010;17:209

Latest NICE guidance on chronic heart failure

BJ Cardio Staff

Abstract

The new guideline, which covers the management of heart failure in adults in primary and secondary care, contains new and updated recommendations on diagnosis, pharmacological treatment, monitoring and rehabilitation. Key priorities for implementation in the guidance include: Referring patients with suspected heart failure and previous myocardial infarction (MI) to transthoracic Doppler 2D echocardiography and specialist assessment within two weeks. Measuring serum natriuretic peptides in patients with suspected heart failure without previous MI; referring those with very high levels of serum natriuretic peptides to urgent transthoracic Dopp

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News from the 2010 Congress of the European Society of Cardiology

September 2010 Br J Cardiol 2010;17:211-14

News from the 2010 Congress of the European Society of Cardiology

Abstract

Highlights of this year’s European Society of Cardiology Congress, held in Stockholm, Sweden, from August 28th to September 1st included a new drug which benefits heart failure by slowing heart rate, and more exciting results from oral compounds that could replace warfarin in various indications. Highlights of this year’s European Society of Cardiology Congress, held in Stockholm, Sweden, from August 28th to September 1st included a new drug which benefits heart failure by slowing heart rate, and more exciting results from oral compounds that could replace warfarin in various indications. SHIFT: ivabradine shows benefit in heart failure

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September 2010 Br J Cardiol 2010;17:209

In Brief

BJ Cardio Staff

Abstract

New NT-proBNP test Roche Diagnostics has announced the launch of a new NT-proBNP+ test, which it says can give a result in under 15 minutes when tested on its cobas h232 near-patient testing meter. In addition, the test has an extended measuring range (60 – 9000pg/ml). The test can serve as an aid in the diagnosis of suspected heart failure, in the monitoring of compensated left ventricular dysfunction and in the risk stratification of patients with acute coronary symptoms. Recent recommendations of a consensus group (Br J Cardiol 2010;17:76-80) highlight the importance of B-type natriuretic peptide (NP) testing for heart failure. NP testi

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July 2010 Br J Cardiol 2010;17:163-5

Eplerenone beneficial in mild heart failure 

BJ Cardio Staff

Abstract

According to Pfizer, an interim analysis of the trial showed that patients treated with eplerenone in addition to current standard of care experienced a significant reduction in risk of cardiovascular death or heart failure hospitalisation compared with those in the placebo arm of the trial.  The company says it is now working to ensure that all patients are informed of this decision, and an amendment to the protocol will be requested to allow all consenting patients to start treatment with eplerenone in an open-label extension of the study, after completing a close-out visit ending the double-blind, placebo-controlled phase.  Eplerenone is

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May 2010 Br J Cardiol 2010;17:s10-s12

ARBs in chronic heart failure

Theresa McDonagh

Abstract

Current treatments The National Institute for Health and Clinical Excellence (NICE) published guidelines on the diagnosis and management of chronic heart failure in 2003,5 with more recent guidelines being published by the European Society of Cardiology (ESC)6 in 2008. The treatment algorithm recommended for patients with heart failure due to left ventricular systolic dysfunction in the ESC guideline is shown in figure 1. Figure 1. Treatment strategy for use of drugs and devices in patients with symptomatic heart failure and systolic dysfunction Based on these guidelines, current first-line pharmacological therapy comprises a combination of o

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In brief

May 2010 Br J Cardiol 2010;17:117

In brief

BJ Cardio Staff

Abstract

New pocket-sized visualisation tool This new pocket-sized visualisation tool provides ultrasound technology at the point-of-care. Similar in size to a mobile phone and weighing less than one pound, it can give high quality colour images enabling physicians to take a quick look inside the body and detect disease earlier. Vscan™ is marketed by GE Healthcare and has received the CE Mark by the European Union. Heart failure report published A comprehensive review of the quality of heart failure care in England Bridging the quality gap: heart failure, has been published by The Health Foundation. It highlights that prevention is key to imp

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March 2010 Br J Cardiol 2010;17:67-8

Cardiorenal syndrome: one disease – two paths?

Abstract

Introduction That renal and cardiac disease appear inseparable from an epidemiological perspective is unsurprising, since they share many risk factors, notably hypertension, diabetes and inflammation. To date, however, our focus on the disparate specialities of ‘cardiology’ and ‘nephrology’ has reinforced a perception of each system as separate. The Cardiorenal Forum (CRF) was established to challenge this perspective. The most recent meeting, last autumn, ‘Optimising care at the cardiorenal interface’ was organised by the Royal College of Physicians, the British Cardiovascular Society and the Renal Association, in association wit

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