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Tag Archives: biomarker

March 2009 Br J Cardiol 2009;16:65

In brief

BJCardio editorial staff

Abstract

BNP as a biomarker study A new study has suggested that using N-terminal brain natriuretic peptide (BNP) as a marker to guide therapy in the treatment of heart failure, is not associated with any improvement in all-cause outcome over conventional symptom-guided therapy (JAMA 2009;301:383–92). The study (Trial of Intensified vs. Standard Medical Therapy in Elderly Patients With Congestive Heart Failure [TIME-CHF]) was performed in 499 patients age 60 years or older hospitalised for heart failure within the past year and with N-terminal BNP levels at least twice the upper limit of normal. The subjects were randomised to receive treatment to r

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