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Pacing supplement: Drugs with devices in the management of heart failure

October 2018 Br J Cardiol 2018;25(suppl 3):S20–S24 doi:10.5837/bjc.2018.s15

Pacing supplement: Drugs with devices in the management of heart failure

Balrik Singh Kailey, Christopher Allen, Badrinathan Chandrasekaran

Abstract

Introduction Device therapy has revolutionised the landscape of heart failure over the past 10 years. Prior to device therapy, the most important trials in heart failure (HF) management centred on pharmacotherapy. The CONSENSUS (Cooperative North Scandinavian Enalapril Survival Study) trial (1987),1 showed the importance of optimal blockade of the renin–angiotensin–aldosterone system (RAAS). Similarly, CIBIS-II (Cardiac Insufficiency Bisoprolol Study II) (1999)2 and RALES (Randomized Aldactone Evaluation Study) (1999)3 trials did the same for beta-blockade and spironolactone, respectively. This century, device therapy has also become part

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