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November 2021 Br J Cardiol 2021;28:155–62 doi:10.5837/bjc.2021.051

Transcatheter mitral valve intervention

Rea Ganatra, Robert Smith

Abstract

Introduction In western populations, mitral regurgitation (MR) is the second most common valvular heart disorder, after aortic stenosis, with a reported prevalence of approximately 2%. This prevalence increases with age and affects up to 10% of those over the age of 75.1,2 Severe MR tends to run an insidious yet malignant course and, without intervention, confers a poor prognosis. Untreated, it is associated with progressive left ventricular remodelling, and ultimately dysfunction, resulting in increased morbidity and an annual mortality rate of 5%.3-5 Mitral valve surgery (MVS), typically mitral valve repair (MVr), for severe degenerative MR

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