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Tag Archives: community cardiology

Early clinical experience with sacubitril/valsartan from a large UK tertiary centre

July 2019 Br J Cardiol 2019;26(suppl 1):S9-S14 doi:10.5837/bjc.2019.s03

Early clinical experience with sacubitril/valsartan from a large UK tertiary centre

Danish Ali, Jacqui Hyland, Fiona Riley, Stephanie Kirkland, Lisa Hinnit, Sarah Albarad, Rajen Parekh, Catherine Watson, Hayley Nicholson, Johanna McCann, Victoria Allport, Fraz Umar, Prithwish Banerjee

Abstract

Introduction Much progress has been made over the last 30 years in the discovery of evidence-based pharmacological treatments that improve morbidity and mortality in people with heart failure with reduced left ventricular ejection fraction (HFrEF). Landmark trials first established angiotensin-converting enzyme (ACE) inhibitors as the mainstay therapy for heart failure (HF),1-3 with angiotensin II receptor blockers (ARB) subsequently demonstrating similar benefits for patients intolerant to ACE inhibitors.4 Further trials reported improved outcomes with mineralocorticoid receptor antagonists (MRA) used together with ACE inhibitors in HFrEF.5

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