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March 2012 Br J Cardiol 2012;19(Suppl 1):s1-s16

Lipids and CVD: improving practice and clinical outcome

Abstract

This supplement is a report from the inaugural meeting of the Cardiometabolic Forum, jointly organised by the British Journal of Cardiology and HEART UK – The Cholesterol Charity. The meeting was held at the Royal Pharmaceutical Society, London, on 24th November 2011. Meeting chairs were Dr Dermot Neely (Royal Victoria Infirmary, Newcastle upon Tyne) for HEART UK, and Dr Henry Purcell (Royal Brompton Hospital, London, and Editor) for BJC. We hope this supplement will provide readers with an independent overview on recent developments in our knowledge of cholesterol metabolism and its implications for clinical practice. Speakers Dermot Neely

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Translating evidence to practice

March 2012 Br J Cardiol 2012;19(Suppl 1):s1-s16 doi:10.5837/bjc.2012.s04

Translating evidence to practice

Jane Skinner

Abstract

Statins represent the cornerstone of treatment in guidelines for lipid management.1 The clinical benefits have been confirmed by meta-analysis of major prospective studies which showed that statins reduced cardiovascular risk by about one fifth per mmol/L reduction in low-density lipoprotein (LDL) cholesterol, largely irrespective of the initial lipid profile, the presence of diabetes, or other presenting characteristics.2,3 More intensive regimens produced further incremental benefit, compared with conventional-dose statin therapy.4 Among patients at higher risk, such as those with pre-existing coronary heart disease (CHD) or with diabetes,

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