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Tag Archives: macular degeneration

January 2009 Br J Cardiol 2009;16(Suppl 2):S3-S8

Current treatment of wet age-related macular degeneration: determining the cardiovascular risk

Frank Enseleit, Stephan Michels, Frank Ruschitzka

Abstract

Methods The leading journals that publish basic science and clinical research in the area of cardiovascular and ophthalmological diseases, and MEDLINE using PubMed, were scanned. The main terms used were “age-related macular degeneration”, “cardiovascular disease”, “ranibizumab”, “bevacizumab”, “pegaptanib” and “VEGF”. The publications were largely selected from the past five years, but older publications which are commonly referenced or highly regarded were not excluded. The reference lists of articles identified by this search strategy were screened and relevant articles were selected. Review articles are cited to pr

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January 2009 Br J Cardiol 2009;16(Suppl 2):S14-S15

Efficacy and safety of intravitreal pegaptanib sodium in the treatment of neovascular age-related macular degeneration

Sobha Sivaprasad, John J Wroblewski

Abstract

Efficacy The Vascular Endothelial Growth Factor Inhibition Study in Ocular Neovascularization (VISION) trial showed that 70% of patients with wet AMD treated for 12 months with six-weekly pegaptanib sodium responded to treatment (lost <15 letters). This compared with only 55% of control (sham) subjects. Furthermore, 6% of patients receiving pegaptanib experienced an improvement in their vision (gained ≥15 letters).2 In a retrospective analysis performed to acquire data on ‘real-life’ experience with pegaptanib, data were collected from 164 patients with any angiographic subtype of sub-foveal choroidal neovascularisation secondary to

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