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Novel potassium binders: a clinical update

April 2021

Novel potassium binders: a clinical update

Hon-Ting Wai, Nirmol Meah, Ravish Katira

Abstract

Hyperkalaemia in heart failure HK is a potentially life-threatening electrolyte abnormality. There is no universal definition of HK; however, a serum level greater than 5.0–5.5 mmol/L is generally regarded as abnormal.4 The Swedish heart failure registry showed an increased mortality associated with abnormal serum potassium.5 Hypokalaemia is associated with increased long-term mortality, as opposed to HK’s association with increased short-term mortality.5 The incidence of HK in heart failure remains highly variable.4,6,7 In PARADIGM-HF, enalapril was compared with the combination drug sacubitril/valsartan. The latter had a hazard ratio of

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Novel potassium binders: a clinical update

April 2021 doi:10.5837/bjc.2021.014

Novel potassium binders: a clinical update

Hon-Ting Wai, Nirmol Meah, Ravish Katira

Abstract

Hyperkalaemia in heart failure HK is a potentially life-threatening electrolyte abnormality. There is no universal definition of HK; however, a serum level greater than 5.0–5.5 mmol/L is generally regarded as abnormal.4 The Swedish heart failure registry showed an increased mortality associated with abnormal serum potassium.5 Hypokalaemia is associated with increased long-term mortality, as opposed to HK’s association with increased short-term mortality.5 The incidence of HK in heart failure remains highly variable.4,6,7 In PARADIGM-HF, enalapril was compared with the combination drug sacubitril/valsartan. The latter had a hazard ratio o

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