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Tag Archives: Proprotein convertase subtilisin/kexin type 9 (PSCK9) inhibitors

October 2019 Br J Cardiol 2019;26(4) doi:10.5837/bjc.2019.036 Online First

PCSK9 inhibitors in familial hypercholesterolaemia: a real-world experience and a meta-analysis

Harshal Deshmukh, Deepa Narayanan, Maria Papageorgiou, Yvonne Holloway, Sadaf Ali, Thozhukat Sathyapalan

Abstract

Introduction Familial hypercholesterolaemia (FH) is a monogenic disorder characterised by excessive levels of low-density lipoprotein-cholesterol (LDL-C) and associated with significant cardiovascular morbidity and mortality.1 A reduction in LDL-C levels is the mainstay of treatment in FH and evidence-based guidelines have proposed treatment goals for these patients. The National Institute for Health and Care Excellence (NICE) recommends at least a 50% reduction in LDL-C levels from the baseline measurement in patients with FH,2 while the European Atherosclerosis Society and the International FH Foundation suggest target LDL-C levels of <2

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