Tag Archives: skin barrier dysfunction

Introduction Atopic dermatitis (AD) is a chronic inflammatory skin condition characterised by dry, inflamed, and pruritic skin due to skin barrier dysfunction.1 This often results in painful, open skin lesions that serve as a breeding ground for infection. This condition creates a vicious cycle as an impaired skin barrier leads to itchy skin, which triggers scratching behaviour, leading to further damage to the skin.2 AD is notably common, with a lifetime prevalence of 15–30% in children and 2–10% in adults.3 First-line management in primary care consists of regular emollients, avoidance of certain triggers and short courses of topical c