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Initial experience of introducing sacubitril/valsartan in a UK heart failure service

July 2019 Br J Cardiol 2019;26(suppl 1):S15-S19 doi:10.5837/bjc.2019.s04

Initial experience of introducing sacubitril/valsartan in a UK heart failure service

Richard J Crawley, Geraint Morton, Navneet Kalsi, Paul R Kalra, Kaushik Guha

Abstract

Introduction Heart failure (HF) remains a significant problem globally.1 In the UK, the prevalence is estimated at over 500,000 individuals,2 with care representing 2% of National Health Service (NHS) resources (approximately £2.3 billion).3 A large proportion of the economic burden relates to lengthy and recurrent hospitalisations. Despite advancements, HF is still associated with a poor prognosis. The National Heart Failure Audit from England and Wales demonstrates an in-hospital mortality rate of around 9%, and a one-year mortality of just over 23%.4 Treatment for patients suffering from HF with reduced ejection fraction (HFrEF) is primar

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