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Clinical articles

May 2005 Br J Cardiol 2005;12:219-23

Sleep-disordered breathing and heart failure: an opportunity missed?

Ali Vazir, Mary J Morrell, Anita K Simonds, Hugh F Mcintyre

Abstract

Sleep-disordered breathing (SDB) is common in patients with congestive heart failure (CHF). SDB appears to be associated with accelerated progression of heart failure. However, it is seldom recognised in cardiology clinics, especially as CHF patients with SDB rarely report symptoms specific to SDB, such as excessive day-time sleepiness. The term SDB incorporates both central sleep apnoea (CSA) and obstructive sleep apnoea (OSA). CSA is thought to be a consequence of heart failure, whereas OSA is thought to be associated with hypertension and excessive sympathetic nerve activation, which may exacerbate failure of the heart through haemodynamic and mechanical mechanisms. The treatment of SDB is likely to be an important complementary step in the management of heart failure, particularly OSA, where treatment with continuous positive airway pressure is well established and significant improvements in left ventricular ejection fraction plus quality of life have been reported. The treatment of CSA remains unclear and requires further research. This review will examine the prevalence, diagnosis, pathophysiology, clinical features and treatment of SDB in patients with CHF.

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May 2005 Br J Cardiol 2005;12:211-8

Aldosterone: an important mediator of cardiac remodelling in heart failure

Allan D Struthers

Abstract

Aldosterone is intimately linked to the pathophysiology of heart failure, and high levels of aldosterone are associated with worse prognosis. Many non-renal effects of aldosterone contribute to the congestive heart failure syndrome, including endothelial dysfunction, reactive myocardial fibrosis and cardiac remodelling. The precise mechanism by which aldosterone stimulates myocardial collagen accumulation and fibrosis is not yet fully understood. It may largely occur secondary to aldosterone-related endothelial dysfunction and inflammation, since endothelial dysfunction can lead to micro-thrombus formation and tissue micro-infarction, which repairs itself by fibrosis. Other contributory effects may include a direct impact of aldosterone on the collagen synthesis pathway.
In the RALES study, spironolactone in conjunction with an angiotensin-converting enzyme (ACE) inhibitor was found to reduce mortality in chronic moderate-to-severe heart failure; the EPHESUS study more recently reported significant reductions in death and hospitalisation when eplerenone was added to ACE inhibitor and beta blocker therapy in patients with clinical evidence of heart failure following acute myocardial infarction. Clinicians should now consider routinely adding an aldosterone receptor antagonist to standard therapy of patients with left ventricular dysfunction and heart failure in order to reduce cardiac morbidity and mortality.

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May 2005 Br J Cardiol 2005;12:205-8

Heart failure after myocardial infarction: a neglected problem?

Martin R Cowie, Larry Lacey, Maggie Tabberer

Abstract

Improvements in the management of acute myocardial infarction together with population ageing have contributed to a growing burden of heart failure. Around half of new cases of heart failure in patients aged less than 75 years are due to coronary artery disease; many of these patients develop heart failure in the context of acute myocardial infarction. Left ventricular systolic dysfunction is the single most common cause of heart failure after myocardial infarction. Of the estimated 65,000 new cases of heart failure in the UK each year, it is likely that around 15,000 occur in the context of acute myocardial infarction. Ventricular remodelling generally occurs in the early period after myocardial infarction, and early identification offers the potential to modify this process and reduce the risk of heart failure. Clear guidelines should be built into the myocardial infarction care pathway to ensure an integrated approach from hospital and community services.

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March 2005 Br J Cardiol (Acute Interv Cardiol) 2005;12:AIC 9–AIC 14

Elevation of troponin I in acutely ill medical patients: a pilot study and literature review

Jonathan Watt, Andrew P Davie, Anne Cruickshank

Abstract

Previous studies have identified a significant incidence of clinically unrecognised myocardial ischaemia in intensive care unit (ICU) patients, as determined by elevation of serum troponin. This pilot study demonstrates a similar high frequency of such a phenomenon in patients who are acutely ill, but without clinical evidence of myocardial ischaemia, on the general medical wards of a large city hospital. Elevation of serum troponin in these patients is associated with higher hospital mortality and increased lengths of hospital stay. Recognition that slight elevation of troponin levels may occur in the context of significant medical illness in acute general medical ward patients is important as it may avoid erroneous diagnosis of myocardial infarction and subsequent unnecessary investigations. A literature review of the various causes of an elevated troponin result is then presented.

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March 2005 Br J Cardiol (Acute Interv Cardiol) 2006;13:AIC 14–AIC 18

Risk of death, MI and patterns of care delivered in non-ST elevation ACS patients with intermediate elevations in cardiac troponin T: a UK DGH experience

Kausik Ray, James Bolton, Alice Veitch, Paul Sheridan, Michael Gillett, Ahmed Al Rifai, Ramasamy ManivArmane, Alan Brennan, Gillian Payne, Wazir Baig

Abstract

Abstract Prior studies have suggested a gradation in clinical risk with increasing elevations of cardiac troponins in patients with non-ST elevation acute coronary syndromes (ACS). We hypothesised that patients with cardiac troponin-T (cTnT) between 0.01-0.1 μg/L might
be perceived as a low-risk group and consequently receive less active medical treatment.

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March 2005 Br J Cardiol (Acute Interv Cardiol) 2005;12:AIC 27–AIC 30

Delivering a modern PCI service: can we change with the times?

Michael S Norell, Saib S Khogali, James M Cotton, Michael R Cusack

Abstract

The volume and complexity of patients undergoing percutaneous coronary intervention (PCI) is growing steadily. This, and the increasing tendency for these procedures to be unplanned, requires us to rethink the way we deliver care in this setting. This article addresses the processes involved, which include pooling of PCI lists, multidisciplinary team meetings and integrated care pathways for both elective and unplanned cases. The value of pre-assessment clinics, specific cardiac triage teams and “generic” catheter lab workers is also discussed. More traditional elements of the service such as on-call rotas are reappraised. Newer concepts, like dedicated PCI meetings to plan strategy and review previous problem cases for educational purposes, are also introduced.

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March 2005 Br J Cardiol (Acute Interv Cardiol) 2005;12:AIC 31–AIC 32

Complex cardiac myxoma

David J Fox, Geir J Grötte, Lawrence Cotter

Abstract

Cardiac myxomas are the most common benign intracardiac tumour, and are more common in women. Since many patients suffer from cerebral or systemic embolism, early diagnosis is vital to plan for surgical intervention. Surgical excision is advocated as soon as possible, particularly in left atrial myxoma, because of the high risk of valvular obstruction and systemic embolisation. Patients with a family history of the disorder are at greater risk of tumour recurrence.

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March 2005 Br J Cardiol 2005;12:156-60

The definition of maximally tolerated blood pressure treatment

Terry McCormack, Mark Davis

Abstract

The new General Medical Services contract has introduced the term ‘maximally tolerated blood pressure treatment’, which it defines as a cut-off point at which a doctor might advise the patient to accept the current blood pressure level. Whilst this is a sensible idea, the contract does not give any guidance as to how the doctor should decide when that point has been reached. In this article the Primary Care Cardiovascular Society considers the issue, looking at available evidence, and publishes a consensus statement on the definition for maximally tolerated blood pressure treatment.

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March 2005 Br J Cardiol 2005;12:146-8

Aneurysms of the sinus of Valsalva following infective endocarditis

Analie Grimshaw, Eu Krishna Adluri, Chris J Smallpeicegénie Di Stefano, Stephen Saltissi

Abstract

Aneurysms of the sinus of Valsalva associated
with infective endocarditis are rare. They can
present during an episode of acute endocarditis
or as late sequelae, with or without rupture. Their
management involves repair of the annulus and closure
of the aneurysm with a Dacron patch.

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March 2005 Br J Cardiol 2005;12:149-54

Organising primary prevention: an approach by multifactorial risk score profile

John M Waddell, Caron Neal

Abstract

Interventions on individual risk factors are most effective when directed at those with highest absolute risk. Joint British Society Guidelines and National Service Frameworks (NSF) indicate that these individuals should be identified. There is a need to continuously categorise the population by risk to identify those for primary prevention. This article describes a project that was set up to use clinical information technology in an innovative way. It was introduced as an administrative routine for the whole population of a large district (Blyth Valley, Northumberland) through the general practices to which the patients belong.

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