Anticoagulation

Programme-Anticoagulation

As so many of the common problems in clinical practice today relate to arterial and venous thrombosis, it is important that all healthcare professionals have a clear understanding of the basics of thrombosis/haemostasis and coagulation/anticoagulation pathways. The underlying final pathophysiological process in myocardial infarction and ischaemic stroke is thrombus formation (thrombogenesis). Other common cardiovascular disorders, such as atrial fibrillation (AF) and heart failure, are also associated with thrombogenesis.

In this updated and revised modular programme we will first be introduced to antithrombotic therapy by examining the mechanism of coagulation and how this relates to the development of arterial and venous thrombosis. Module two will discuss how and why antiplatelet therapy is important, and another module will look at the value of anticoagulant therapy. The latter two modules will be complimented by case studies.

Each module will have a series of multiple-choice questions. Its five hours of learning leads to five continuing professional development (CPD) credits.

The programme has been made available with an educational grant from Bristol Myers Squibb (BMS) and Pfizer UK Limited. It has been independently written by leading UK physicians and pharmacists, and has been endorsed by Anticoagulation Europe, the Atrial Fibrillation Association, and Arrhythmia Alliance – the Heart Rhythm Charity.

Original modular programme written by:
Dr Andrew Blann, Consultant Clinical Scientist, City Hospital, Birmingham
Dr Louise Tillyer (retired)
Mr Sotiris Antoniou, Consultant Pharmacist, Barts Health NHS Trust and North East London Cardiovascular & Stroke Network
 
2016 revisions by:
Dr Matthew Rogers, Locum Consultant Haematologist, Royal Surrey County Hospital (modules 1–4)
Mr Sotiris Antoniou, Consultant Pharmacist, Barts Health NHS Trust and North East London Cardiovascular & Stroke Network (module 5)

Anticoagulation module 1: introduction to antithrombotic therapy

Released 1 April 2016   Programme: Anticoagulation 1 CPD/CME credit

Anticoagulation module 1: introduction to antithrombotic therapy
  • Understand the role of Virchow’s triad
  • Discuss the coagulation cascade
  • Recognise key aspects of platelet function
  • Appreciate the consequences of loss of haemostasis
  • Appreciate the importance of antiplatelet drugs in treating arterial thrombosis
  • Explain the role of anticoagulants in treating venous thrombosis

Anticoagulation module 2: antiplatelet therapy

Released 1 April 2016   Programme: Anticoagulation 1 CPD/CME credit

Anticoagulation module 2: antiplatelet therapy
  • Understand the importance of platelets in pathology
  • Be able to discuss the physiology of the platelet
  • Recognise three major routes for suppressing platelet function
  • Be aware of the mode of action of metabolic inhibitors
  • Appreciate the value of ADP-receptor blockers
  • Explain the uses of GpIIb/IIIa receptor blockers
  • Be prepared for the consequences of mis-management of antiplatelet therapy: haemorrhage

Anticoagulation module 3: anticoagulant therapy

Released 1 April 2016   Programme: Anticoagulation 1.5 CPD/CME credits

Anticoagulation module 3: anticoagulant therapy
  • Understand key aspects of the coagulation pathway
  • Discuss the action of heparin, low molecular weight heparin, fondaparinux and vitamin K antagonists such as warfarin
  • Recognise the mode of action of new oral anticoagulants
  • Appreciate the uses of anticoagulants in acute coronary syndromes and atrial fibrillation
  • Prepare for the consequences of mis-managed anticoagulation, including haemorrhage

Anticoagulation module 4: clinical aspects of anticoagulation

Released 1 April 2016   Programme: Anticoagulation 1 CPD/CME credit

Anticoagulation module 4: clinical aspects of anticoagulation
  • Understand which patients require anticoagulation
  • Be able to assess requirements (scoring systems) for anticoagulation
  • Know how to initiate anticoagulation with vitamin K antagonists (VKA)
  • Understand how to use novel oral anticoagulants (NOACs)
  • Discuss anticoagulation for direct current cardioversion and in invasive procedures

Anticoagulation module 5: the role of the pharmacist

Released 1 April 2016   Programme: Anticoagulation 0.5 CPD/CME credits

Anticoagulation module 5: the role of the pharmacist
  • Discuss the role of the hospital and community pharmacist in the provision of anticoagulant services
  • Understand the initiation of anticoagulants, and patient counselling
  • Provide pragmatic advice on use of warfarin and novel oral anticoagulants