Tag Archives: abnormal neovascularisation

Table 1. Properties and functions VEGF The VEGF system VEGF is not a single protein but rather exists in a number of different isoforms (figure 1). These isoforms differ in the number of amino acids contained in the mature secreted protein and, most importantly, in their solubility and heparin-binding properties.9,10 The solubility of the isoform influences its ability to diffuse in the extracellular space and heparin-binding properties influence the extracellular matrix interactions of the individual isoform. The balance of solubility and heparin binding provides the spatial cues to initiate a precisely branched vessel network.11 A furthe