Tag Archives: ADVANCE

New data on intensive glucose lowering in type 2 diabetes The results of three large trials investigating the clinical effects of intensive glucose lowering in patients with type II diabetes were presented at the recent American Diabetes Association meeting in San Francisco, USA, and have shown somewhat conflicting results. The ACCORD (Action to Control Cardiovascular Risk in Diabetes) trial was stopped earlier this year because of an increased mortality in the intensive glucose lowering group. The two other trials – ADVANCE (Action in Diabetes and Vascular Disease – Preterax and Diamicron MR Controlled Evaluation) and VADT (Veteran’s A

Chairman of the ADVANCE Data Monitoring and Safety Committee, Professor Rory Collins from the University of Oxford, said “The interim results from ADVANCE provide no confirmation of the adverse mortality trend reported from the ACCORD study”. He also noted that the ADVANCE interim results were based on more than twice as much data and similar levels of glucose control as in ACCORD. ADVANCE principal investigator, Professor Stephen MacMahon (The George Institute for International Health in Sydney, Australia), stated that “Due to the unexpected report from the ACCORD trial, we felt it was in the public interest for us to ask our Data Moni