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Tag Archives: alcohol septal ablation

October 2011 Br J Cardiol 2011;18:201-2 doi:10.5837/bjc.2011.001

Alcohol septal ablation for the relief of symptoms in obstructive HCM: a ‘coming of age’

Neha Sekhri, Peter Mills, Charles Knight

Abstract

HCM is conventionally understood as a cardiac disease inherited in an autosomal dominant fashion with incomplete penetrance. Over the past two decades, genetic research has established that HCM has considerable allelic and non-allelic heterogeneity. For the majority of patients, outside of its utility in pre-symptomatic screening, a genetic diagnosis has not made important contributions to clinical management. In large part, this is because most proband patients have apparently unique mutations, and because the fidelity between genotype and phenotype has been poor in families and for mutations studied thus far. Over the last 20 years, the di

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October 2011 Br J Cardiol 2011;18:233-237 doi:10.5837/bjc.2011.005

Alcohol septal ablation in hypertrophic obstructive cardiomyopathy

Tahir Hamid, Matthew Luckie, Rajdeep S Khattar 

Abstract

Introduction Hypertrophic cardiomyopathy (HCM) is an inherited cardiac muscle disorder, transmitted predominantly in an autosomal dominant fashion with variable penetrance and an estimated prevalence of one in 500 in the western population.1 Myocardial hypertrophy most commonly affects the interventricular septum and may be associated with dynamic obstruction of the left ventricular outflow tract (LVOT),2 caused by systolic anterior motion (SAM) of the mitral valve leaflets. LVOT obstruction may occur at rest or only become apparent during physiological stress. Symptoms related to LVOT obstruction include dyspnoea, exertional chest pain, pre-

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January 2006 Br J Cardiol 2006;13:58-61

Alcohol septal ablation for hypertrophic obstructive cardiomyopathy: how and when?

Elliot J Smith, Ajay K Jain, Charles J Knight

Abstract

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