Tag Archives: antihypertensive

The study, published on July 18 in PLoS One, was conducted by Dr David Wald (Wolfson Institute of Preventive Medicine, London) and colleagues. The polypill used contained three antihypertensive medications – the calcium antagonist, amlodipine 2.5 mg; the angiotensin-receptor blocker, losartan 25 mg; and the diuretic, hydrochlorothiazide 12.5 mg – in addition to the cholesterol-lowering agent simvastatin 40 mg. In the study, 86 individuals were randomised to the polypill or placebo for 12 weeks. They then crossed over and took the other treatment. Mean systolic blood pressure was reduced by 17.9 mmHg, diastolic pressure was reduced by 9.8

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