August 2017 Br J Cardiol 2017;24:(3) Online First
BJC Staff, Dr Richard Crawley, Dr Brian Halliday, Dr Rosita Zakeri
Landmark trials in heart failure – 30 years from CONSENSUS With 2017 marking the 30th year since the publication of CONSENSUS,1 which first reported a reduction in mortality with enalapril versus placebo in patients with advanced heart failure (HF), the BCS held a dedicated session to review the seminal clinical trials and advances in chronic heart failure management in this period. Dr Rosita Zakeri (Royal Brompton Hospital, London) reviewed this session for us and spoke to the BJC afterwards. Rosita Zakeri The era of vasodilator therapy for heart failure began in the 1990s. Professor Karl Swedberg (University of Gothenberg, Sweden) began
March 2013 Br J Cardiol 2013;20(suppl 2):S1–S11 doi:10.5837/bjc.2013.s02
Professor Martin Cowie, Professor Derek Bell, Mrs Jane Butler, Professor Henry Dargie, Professor Alasdair Gray, Professor Theresa McDonagh, Dr Hugh McIntyre, Professor Iain Squire, Dr Jacqueline Taylor, Ms Helen Williams
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February 2013 Br J Cardiol 2013;20:18-9
Mineralocorticoid receptor antagonists Professor Faiez Zannad (Université de Lorraine, Nancy, France), the first of two guest lecturers, who has been an investigator in three major randomised controlled trials (RCT) of mineralocorticoid receptor antagonists (MRA) in heart failure,1-3 opened the first session. There was a particular focus on the recent EMPHASIS-HF trial,3 which recruited heart failure (HF) patients with left ventricular systolic dysfunction (ejection fraction [EF] ≤30%, or EF 30-35% with QRS duration >130 ms) and mild symptoms (New York Heart Association [NYHA] class II). Eplerenone treatment resulted in a 37% relative
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