Tag Archives: cardiac glycosides

In the first article, Xanniedes et al. take a look back at the major scientific advances that have led to our current understanding and medical use of digoxin. From ancient wisdom and William Withering’s careful chronicling of the therapeutic benefits and side effects of the common botanical foxglove in dropsy, which still hold true today, to the discovery of its mode of action and eventual rise to become a staple in the management of heart failure (HF) and atrial fibrillation (AF) in the pre-angiotensin-converting enzyme (ACE) inhibitor era. In parallel, the authors highlight a more macabre side to the digoxin story, including issues with