Tag Archives: cardiotoxins

Introduction Breast cancer is one of the major public health problems; it is the second most common cancer among women and it has a high mortality rate.1 Doxorubicin, which is an antibiotic of the anthracycline group, has a cytotoxic antineoplastic activity and is commonly used in a broad spectrum of malignancies, either alone or in combination with other drugs. Despite its usefulness in chemotherapy of breast cancer, its cardiac side effects, such as cardiomyopathy and congestive heart failure, cause considerable limitations and obstacles for oncologists and cardiologists.2,3 Doxorubicin’s cardiotoxicity is mainly due to oxidative stress,