Tag Archives: cytochrome P450 3A4 inhibitors

Introduction A drug–drug interaction (DDI) is a pharmacokinetic (PKI) or pharmacological influence of one medicine on another that differs from the known or anticipated effects of each agent alone. A DDI may result in a change in either drug efficacy or drug toxicity for one or both of the interacting medicines. PKI interactions occur when one medicine alters the absorption, distribution, metabolism, or excretion of another, thus, increasing or decreasing the amount of medicine available to produce its pharmacological effects. Such PKI interactions occurring with one medicine do not necessarily occur uniformly across a group of related med