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May 2024 Br J Cardiol 2024;31:45–8 doi:10.5837/bjc.2024.019

Cardiac ejection fraction as a problematic metric for heart failure phenotyping

Rienzi A Diaz-Navarro, Peter L M Kerkhof

Abstract

Figure 1A. Volume domain representation of data sets referring to acute myocardial infarction patients. End-systolic volume (ESV) is plotted against end-diastolic volume (EDV). The dark blue line indicates a trajectory with a constant value for ejection fraction (EF), in this case 45%. Four patients satisfy this condition, but can be distinguished by considering the distance from the origin to each individual point. This distance is termed the companion to EF, and denoted as EFC. An example (pink-arrowed bar) is shown for the patient with the smallest ventricle having EF=45%. Four patients (marked by the coloured dotted lines referring to th

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