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February 2015 Br J Cardiol 2015;22:11 Online First

Correspondence: accurate classification of chest pain

Drs Yasmin Ismail, Nathan Manghat, and Mark Hamilton

Abstract

Dear Sirs, Statistical probabilistic reasoning is important in understanding the likelihood of ‘false-positive’ (FP) and ‘false negative’ (FN) results when requesting any diagnostic test. In cohorts with a low prevalence of disease, a significant number of positive results are likely to be FP. Conversely, when the disease has high prevalence, FN results increase. Identification of patients with suspected coronary artery disease (CAD) relies on clinical history, examination and electrocardiogram (ECG)/laboratory results. The National Institute for Health and Care Excellence (NICE) define angina as “typical” or “atypical” depend

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