Professor Jignesh K Patel
The human heart has evolved over millennia whereby it is able to pump up to 20 litres per minute upon demand, it can adapt to work efficiently at altitudes of up to 30,000 feet and at high atmospheric pressures under sea. It is not surprising, therefore, that the first attempts at therapies for end-stage heart disease focused on orthotopic transplantation. Certainly, over the last 50 years since Barnard’s first heart transplant, significant advances in immunosuppression and post-transplant management have led to heart transplantation being the optimal long-term solution. One-year survival now exceeds 90% at many in