Tag Archives: hypertrophic cardiomyopathy

Introduction Hypertrophic cardiomyopathy (HCM) predominantly results from genetic variants that affect cardiac sarcomeres. The result is a heterogeneous condition characterised by ventricular hypertrophy that cannot be explained by increased afterload (i.e. arterial hypertension, aortic stenosis). Various hypothesised mechanisms were potentially responsible for a perceived increased risk of arrhythmia during exercise in patients with HCM: dynamic left ventricular outflow tract obstruction (LVOTO) increasing left ventricular pressure and strain; sympathetic vagal imbalance; microvascular ischaemia and metabolic acidosis.1 Subsequent internatio

Figure 1. Electrocardiogram demonstrating deep T-wave inversion in leads 1, aVL, and V2 through to V6 The CMR demonstrated marked asymmetrical hypertrophy of the anterior and anteroseptal walls at basal and mid-ventricular level. The peak basal wall thickness was 25 mm. The reference wall thickness was 7–9 mm. There was also apical circumferential hypertrophy with a peak apical wall thickness of 11 mm and systolic obliteration from distal left ventricle (LV) through to the apex. Perfusion was performed with regadenosine stress. There was severe microvascular ischaemia in a near circumferential pattern basally, and marked ischaemia in the ma

(more…)

No content available

No content available

No content available