Tag Archives: hyporeninaemic hypoaldosteronism

In the midst of the first wave of the COVID-19 pandemic in the United Kingdom, we observed new-onset systolic hypertension associated with hypernatraemia and hypokalaemia with normal serum urea among hospitalised patients. We investigated two patients and found elevated urinary potassium (without causal drugs) and hyporeninaemic hypoaldosteronism (plasma renin <0.2 nmol/L/hr [reference range: 0.5–3.5 nmol/L/hr] and aldosterone <60 pmol/L [reference range: 60–250 pmol/L]) in both. Congenital and secondary endocrine causes of hypertension were excluded. We treated one of the patients with amiloride, which resulted in normalisation of