Tag Archives: laropiprant

New editorial board member Dr Ketan Dhatariya We are delighted to welcome Dr Ketan Dhatariya to our editorial board. Dr Dhatariya is a consultant in diabetes, endocrinology and general medicine at Norfolk and Norwich University Hospital, Norwich. He is also a senior lecturer at the University of East Anglia, and an assistant professor of medicine at St George’s University, Grenada, in the West Indies. He has published on a wide variety of diabetes- and endocrine-related subjects, including diabetes-related foot disease. He serves as meetings secretary for the Association of British Clinical Diabetologists, and medical secretary for the Spec

Nicotinic acid/laropiprant combination launched in UK A combination of nicotinic acid and laropiprant (Tredaptive®), for the treatment of dyslipidaemia (particularly combined mixed dyslipidaemia and primary hypercholesterolaemia) has been launched in the UK by Merck Sharp & Dohme. It should be used in combination with statins when the cholesterol-lowering effect of statin monotherapy is inadequate, and as monotherapy only if statins are thought inappropriate or if they are not tolerated. Diet and other non-pharmacological measures to control lipid levels should be continued. It is hoped that the addition of the anti-flushing agent laropi

Introduction Large intervention studies suggest that while lowering low-density lipoprotein cholesterol (LDL-C) is beneficial, it is insufficient to prevent the majority of coronary heart disease (CHD) events. Niacin improves the overall lipid profile, LDL-C and triglycerides (TG) and is the most effective agent for raising high-density lipoprotein cholesterol (HDL-C) levels.1 Co-administration of niacin with a statin offers the potential for additional lipid management, but the use of niacin has been limited due to associated flushing, mediated primarily by prostaglandin D2 (PGD2).2 Flushing of the face and trunk occurs in nearly all patient