This website is intended for UK healthcare professionals only Log in | Register

Tag Archives: neprilysin

October 2020 Br J Cardiol 2020;27(4) doi:10.5837/bjc.2020.031

Neprilysin inhibitors and angiotensin(1–7) in COVID-19

Nathalie Esser, Sakeneh Zraika

Abstract

The issue regarding use of RAS blockers in the context of COVID-19 has previously been reviewed.1,2 Most recently, emerging data suggest no harm is associated with use of ACE inhibitors or ARBs in COVID-19.3,4 In this perspective, we discuss a related aspect that was first raised by Acanfora and colleagues,5 namely, the potential benefit of neprilysin inhibitors and their role in modulating levels of RAS components. Similar to the situation for ACE inhibitors and ARBs, it seems there are mixed opinions on the utility of neprilysin inhibitors in COVID-19. In a recent review, it was postulated that increasing neprilysin activity might mitigate

| Full text
Applying PARADIGM-HF to the use of sacubitril/valsartan in clinical practice

July 2019 Br J Cardiol 2019;26(suppl 1):S4-S8 doi:10.5837/bjc.2019.s02

Applying PARADIGM-HF to the use of sacubitril/valsartan in clinical practice

Pardeep S Jhund, John J V McMurray

Abstract

Introduction The PARADIGM-HF (Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure) trial demonstrated that the angiotensin receptor/neprilysin inhibitor (ARNI), sacubitril/valsartan (formerly known as LCZ696), was superior to enalapril in reducing the occurrence of adverse cardiovascular (CV) outcomes in patients with heart failure with reduced ejection fraction (≤40%; HFrEF).1,2 The trial was terminated early, on the advice of the independent safety monitoring board, on the basis of clear benefits. These included:1 a 20% relative risk reduction (4.7% absolute risk reduction [ARR

| Full text
Close

You are not logged in

You need to be a member to print this page.
Find out more about our membership benefits

Register Now Already a member? Login now
Close

You are not logged in

You need to be a member to download PDF's.
Find out more about our membership benefits

Register Now Already a member? Login now