June 2024 Br J Cardiol 2024;31:80 doi:10.5837/bjc.2024.024
Edd Maclean, Karishma Mahtani, Maurizio Parker, Rohan Vyas, Roy Bo Wang, Marina Roelas, Nikhil Ahluwalia, Vijayabharathy Kanthasamy, Antonio Creta, Malcolm Finlay, Ross J Hunter, Syed Ahsan, Mark J Earley, Pier D Lambiase, James Elliott, Filip Zemrak, Amal Muthumala, Philip Moore, Simon Sporton, Anthony Chow, Christopher Monkhouse
Introduction In ambulatory individuals with high-grade atrioventricular (AV) block, it is well-established that restoration of AV synchrony with dual-chamber pacing confers important physiological benefits over single-chamber pacing, including improvements in exercise capacity, reduction in incident atrial fibrillation (AF), and avoidance of pacemaker (PPM) syndrome.1,2 The impact of dual-chamber pacing on mortality remains disputed and, in older people, it has been proposed that the expected advantages of physiological pacing strategies may be mitigated by the higher prevalence of comorbidities and non-arrhythmic death.1,3 Accordingly, the
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