Tag Archives: plaque regression

The recently published study (J Am Coll Cardiol 2009;54:1787-94), was conducted by a group led by Dr Justin Lee (University of Oxford). In the study, 71 patients with low high-density lipoprotein (HDL) cholesterol and vascular disease were randomised to modified release nicotinic acid (uptitrated to 2 g daily), or placebo. All patients were already taking statins. Magnetic resonance imaging (MRI) was performed at baseline and at six and 12 months, with blood samples taken at the time of MRI. Results showed that the primary end point of absolute change in carotid artery wall area at one year was reduced by 1.64 mm2 in the niacin group compare