Tag Archives: prostacyclin

Introduction Pulmonary arterial hypertension (PAH) is a devastating disease characterised by irreversible pulmonary vascular proliferation and remodelling, resulting ultimately in right heart failure. Current therapy targets the nitric oxide, endothelin and prostacyclin pathways to promote pulmonary vasodilatation and reduce right ventricular afterload.1,2 Selexipag is an oral selective prostacyclin-receptor agonist that is used in the treatment of PAH. In the GRIPHON (Prostacyclin [PGI2] Receptor Agonist In Pulmonary Arterial Hypertension) trial the optimum dose of selexipag for maximum therapeutic benefit frequently differed between individ

ISHLT overview: advances in transplantation Presenters shared the importance of increasing the source of hearts for transplantation through donation after cardiac death (DCD). “The lack of suitable donor hearts for transplantation has severely limited access to this life saving therapy for patients with advanced heart failure,” said Andrew Fisher (Professor of Respiratory Transplant Medicine, University of Newcastle). “The ability to safely perform DCD heart transplant together with improved overall management of potential heart donors represents a substantial step forward in addressing this clinical challenge,” he concluded. 40% in