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Introduction Postural orthostatic tachycardia syndrome (PoTS) is a heterogenous group of disorders of autonomic disturbance characterised by the clinical symptoms of orthostatic intolerance, mainly light-headedness, fatigue, sweating, tremor, anxiety, palpitations, exercise intolerance and near syncope on upright posture.1 The pathogenesis is poorly understood, with various theories existing including neuropathic and autoimmune aetiologies.2 It is a condition that mainly affects young individuals, with a female preponderance. The true prevalence of PoTS is unknown, a North American study predicted that it may affect up to 170 per 100,000 indi