Tag Archives: sodium-glucose cotransporter 2 (SGLT2) inhibitors

Introduction Heart failure with reduced ejection fraction (HFrEF) is a significant healthcare burden internationally, with an age-standardised prevalence of approximately 3.8% in women and 4.6% in men, and an estimated five-year mortality rate of 43%.1,2 Hospitalisations for heart failure exacerbations represent a major financial challenge to health services, and such patients have a higher risk of readmission and mortality.3 Previously, the DAPA-HF (Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction) trial demonstrated that dapagliflozin significantly reduces the risk of worsening heart failure and cardiovascular deat

Introduction The European Society of Cardiology (ESC) heart failure guideline has undergone major updates every few years, with recent publications being in 2016 and 2021, respectively.1,2 Advances within heart failure care continue at pace, with presentation and publication of key randomised-controlled trials (RCTs) and meta-analyses being seen at the major cardiology scientific congresses. Given the likely impact of several trials on heart failure management and patient outcomes, the decision was made to publish a focused update in 2023 incorporating the most recent data.3 After robust review by the ESC guideline task force, only trials th