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March 2021 Br J Cardiol 2021;28:30–4 doi:10.5837/bjc.2021.011

Takotsubo syndrome: the broken-heart syndrome

Rienzi Díaz-Navarro

Abstract

Background Takotsubo syndrome (TTS) – also known as broken-heart syndrome, Takotsubo cardiomyopathy, and stress-induced cardiomyopathy – is a recently discovered acute cardiac disease first described in Japan in 1991.1 TTS has a clinical presentation with chest pain, ischaemic electrocardiographic (ECG) changes, and elevation of biomarkers, such as cardiac troponin and brain natriuretic peptide (BNP), triggered by significant emotional or physical stress, and accompanied by distinct patterns of transient left ventricular dysfunction.2,3 This contractile dysfunction classically adopts an apical ballooning shape of the left cardiac chamber

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