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Triglyceride-rich lipoproteins and their role in cardiovascular disease

May 2023 Br J Cardiol 2023;30(suppl 2):S4–S9 doi:10.5837/bjc.2023.s06

Triglyceride-rich lipoproteins and their role in cardiovascular disease

Chris J Packard

Abstract

Introduction Triglycerides (TG) and cholesterol are water-insoluble molecules that are transported through the aqueous medium of plasma in large quantities from sites of absorption, synthesis or storage to tissues that require them for cell functions such as energy production. To enable transport to occur, these lipids are solubilised into plasma lipoproteins which have the general structure of a lipid-filled core and a surface of phospholipid and specific proteins. It is the proteins that direct the fate of the contained lipid by interacting with key lipolytic enzymes and cell membrane receptors. Figure 1 depicts the general structure of lip

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