Tag Archives: Women’s Health Initiative

The study, presented at the North American Menopause Society 2012 Annual Meeting held in Orlando, Florida, US, involved 700 women who took either oral conjugated equine oestrogens (Premarin®) 0.45 mg/day (lower than the 0.625 mg/day used in the Women’s Health Initiative [WHI] study), transdermal oestradiol (Climara®) 50 micrograms/day, or placebo. Women taking the active oestrogens received 200 mg of micronised progesterone for 12 days each month. As expected, both types of hormone therapy relieved menopausal symptoms, such as hot flushes and night sweats and had favourable effects on bone mineral density compared with placebo. WHI resu

In the present study, researchers analysed data from the WHI on 153,840 post-menopausal women, of whom 7% were taking statins at baseline. During the study period, 10,242 incident cases of diabetes were reported. In an unadjusted risk model, statin use at baseline was associated with a 71% increased risk of diabetes, but after adjusting for other risk factors, this was reduced to a 48% increased risk. The association appeared to be a class effect. Risk was increased particularly in white, Hispanic, and Asian women, but not in African American women. The association was also observed at all levels of body mass index (BMI) but women with the lo