Homocysteine – is it the end of the line?

For nearly 40 years it has been suggested that high levels of homocysteine are associated with an increased risk of cardiovascular disease and that lowering these levels might be beneficial. On the basis of recently-published evidence, however, it appears that this hypothesis no longer holds and it is, perhaps, now time to move on in the search for non-conventional cardiovascular risk factors and other markers of disease risk.