The Framingham and UKPDS (United Kingdom Prospective Diabetes Study) risk equations overestimate the probability of cardiovascular events in people with type 2 diabetes, according to several studies presented at the International Diabetes Federation 2009 meeting held in October in Montreal, Canada.
In one study, a group led by Dr Andre Pascal Kengne (University of Sydney, Australia), noted that data from the recent ADVANCE (Action in Diabetes and Vascular Disease) trial conducted in more than 7,000 patients with diabetes worldwide, suggested that the UKPDS equation overestimated risk of major coronary heart disease (CHD) by 198%, and the two Framingham equations overestimated the risk by 146% and 289%. A group from Greece led by Dr Athanasios Kofinis (National University of Athens) reported similar findings from a five-year study of more than 900 people with diabetes.
