Tag Archives: acute coronary syndrome (ACS)

Introduction Control of hypercholesterolaemia has been established as a highly effective first-line management in acute coronary syndrome (ACS) patients.1,2 Data from a meta-analysis of randomised-controlled trials demonstrated that for each 1 mmol/L reduction in low-density lipoprotein (LDL)-cholesterol (LDL-C), statins reduced major cardiovascular (CV) events (myocardial infarction [MI], CV death, any stroke or coronary revascularisation) by an estimated 22%.3 National Institute for Health and Care Excellence (NICE) and international guidelines recommend fasting lipid profiles before, and within three months following, the initiation of hi

Introduction Dual antiplatelet therapy (DAT) with aspirin and clopidogrel is recommended for up to one year following acute coronary syndrome (ACS) in order to reduce the risk of further cardiac events.1,2 Gastrointestinal bleeding is the main hazard of this treatment; however, although the incidence of bleeding is low, it results in significantly increased morbidity and mortality in these patients,3-5 and proton pump inhibitors (PPIs) are often prescribed to selective patients to reduce this risk. PPIs act by reducing the secretion of gastric acid, neutralising gastric pH, increasing clot formation and decreasing the lysis of blood clots. Th