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Tag Archives: anti-Xa activity

Dose capping of enoxaparin results in sub-therapeutic anti-Xa level

April 2011 Br J Cardiol 2011;18:82–3

Dose capping of enoxaparin results in sub-therapeutic anti-Xa level

Kristopher S Lyons, Vivienne Nesbitt, Ian B A Menown

Abstract

Introduction The low molecular weight heparin (LMWH) enoxaparin is recommended by the European Society of Cardiology as an antithrombotic agent for the treatment of acute coronary syndromes (ACS) (class I level A indication in the treatment of acute ST-elevation myocardial infarction [MI] along with thrombolytic therapy and class IIa level B recommendation in the treatment of ACS without ST elevation).1,2 A dosing strategy of 1 mg/kg twice daily is recommended as higher doses have been shown to result in increased bleeding without further clinical benefit.3 Weight-adjusted dose reduction is advised in patients >75 years and in those with

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