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Tag Archives: direct oral anticoagulants (DOACs)

December 2020 Br J Cardiol 2020;27:124–5 doi:10.5837/bjc.2020.036

DOACs for stroke prevention in patients with AF and cancer

Dipal Mehta, Avirup Guha, Peter K MacCallum, Amitava Banerjee, Charlotte Manisty, Thomas Crake, Mark Westwood, Daniel M Jones, Arjun K Ghosh

Abstract

Background Atrial fibrillation (AF) occurs at an increased frequency in patients with cancer, however, the link between cancer and AF is not fully understood.1,2 Stroke prophylaxis with anticoagulation is important; however, this can prove challenging in the setting of active malignancy, which predisposes to an increased risk of haemorrhage, as well as thrombosis.3 Traditionally, low molecular weight heparin (LMWH) and warfarin have been used in this setting. There remains limited evidence for direct oral anticoagulants (DOACs) in cancer patients for stroke prophylaxis in AF (SPAF). However, small observational studies have demonstrated compa

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