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January 2008 Br J Cardiol 2008;15:40-5

Chronic transfusion, iron overload and cardiac dysfunction: a multi-dimensional perspective

Hussain Isma’eel, Maria D Cappellini, Ali Taher

Abstract

Introduction Table 1. Differentiating thalassaemia major and intermedia Thalassaemia was first described as a significant problem in the UK in the mid-1950s and was predominantly observed in patients of African or Mediterranean descent. By 1998, more than 800 patients with thalassaemia major were included on the UK Thalassaemia Register.1 As with thalassaemia major, patients with thalassaemia intermedia have a homozygous genotype (i.e. have inherited an affected beta-gene from both parents) but they demonstrate milder clinical symptoms. The clinical phenotypes of thalassaemia intermedia lie between those of thalassaemia minor and major. Altho

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