This website is intended for UK healthcare professionals only Log in | Register

Tag Archives: ISCHEMIA trial

January 2021 Br J Cardiol 2021;28:5–6 doi:10.5937/bjc.2021.004

ISCHEMIA trial: do the new stable chest pain guidelines need updating?

Khaled Alfakih, Saad Fyyaz, Andrew Wragg

Abstract

The recently published ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial is likely to change this practice.5 The ISCHEMIA trial compared medical therapy with invasive management in patients with proven ischaemia, after excluding patients with left main stem (LMS) stenosis with CTCA, and found no difference in outcome. We suggest that the ISCHEMIA trial results are likely to shift clinical practice towards CTCA as the primary diagnostic test for new chest pain. Current guidelines The updated ESC guidelines1 on new stable chest pain, published in 2019, recommended investigation based o

| Full text

October 2020 Br J Cardiol 2020;27:112–4 doi:10.5837/bjc.2020.033

Should we still have the COURAGE to perform elective PCI in stable myocardial ISCHEMIA?

Telal Mudawi, Darar Al-Khdair, Muath Al-Anbaei, Asmaa Ali, Ahmed Amin, Dalia Besada, Waleed Alenezi

Abstract

The evidence COURAGE This study compared PCI plus optimal medical therapy with optimal medical therapy alone. There were 2,287 patients enrolled: 1,149 patients were equally randomised to receive PCI or medical therapy, testing all-cause mortality and myocardial infarction (MI) over a median of 4.6 years. The cumulative primary-event rates were not significantly different between the two groups (p=0.62). The same was the case for the composite of death, MI, and stroke (p=0.62); acute coronary syndrome (ACS) hospitalisation (p=0.56), or MI (p=0.33). The trial concluded that elective PCI confers no prognostic benefit over medical therapy alone.

| Full text
Close

You are not logged in

You need to be a member to print this page.
Find out more about our membership benefits

Register Now Already a member? Login now
Close

You are not logged in

You need to be a member to download PDF's.
Find out more about our membership benefits

Register Now Already a member? Login now