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Tag Archives: LDL targets

July 2008 Br J Cardiol 2008;15:205–9

Efficacy of ezetimibe and future role in the management of refractory hyperlipidaemia in high-risk patients

Rizwan Sarwar, Clare Neuwirth, Shahenaz Walji, Yvonne Tan, Mary Seed, Gilbert R Thompson, Rossi P Naoumova

Abstract

Introduction About 10 million deaths in the world are caused each year by coronary heart disease (CHD) and stroke.1 Comparative statistics in Britain2 are on a smaller scale but in relative terms, similar. Total mortality in the UK is approximately 600,000 annually, 36% of which is due to cardiovascular disease. Half of the latter is from CHD, a quarter from stroke and it is the main cause of premature mortality in both men and women. Recently it was estimated that the major modifiable risk factor, raised serum cholesterol, accounted for 45% of all myocardial infarcts in Western Europe.3 The introduction of statins 20 years ago has revolution

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